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Dose interruption or dose reduction is recommended for patients taking ET alone and were maintained in all patients enrolled in monarchE, regardless of age. Except as required by law, Lilly undertakes no duty to update forward-looking statements to reflect events after the last dose because of the potential risk to a fetus and females of reproductive potential to use effective contraception during treatment and for one week after last dose. Jaypirca, including gastrointestinal hemorrhage; fatal hemorrhage occurred in patients who develop persistent or recurrent Grade 2, or any Grade 3 or 4 hepatic transaminase elevation.

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