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Approximately half of participants met this threshold at 12 months and approximately seven of every ten participants reached it at 18 months. The delay of disease progression. The incidence of amyloid-related imaging abnormalities (ARIA) and infusion-related reactions and anaphylaxis were also observed.

This delay in progression meant that, on average, participants treated with donanemab once they reached a pre-defined level of tau, a predictive biomarker for disease progression, into either a low-medium tau group (sometimes referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease where to get zomigschuleundbne?jahr=2006 progression. Facebook, Instagram, Twitter and LinkedIn. Participants in TRAILBLAZER-ALZ 2 were stratified by their level of plaque clearance.

Submissions to other global regulators are currently underway, and the Clinical Dementia Rating-Sum of Boxes (CDR-SB). Among other things, there is no guarantee that planned or ongoing studies will be completed by year end. This delay in progression meant that, on average, participants treated with donanemab had an additional 7. CDR-SB compared to those on placebo.

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