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Dose Modifications and Discontinuations: ARs led to dosage reductions in 4. Patients: fatigue (29; 1. Patients: hemoglobin decreased (42; 9), platelet count decreased (32; 15), creatinine increased (30; 1. Drug InteractionsStrong CYP3A Inhibitors: Concomitant use with Jaypirca decreased pirtobrutinib systemic exposure, which may reduce Jaypirca efficacy. Infectious, neoplastic, and other causes for such symptoms should be excluded by means of appropriate investigations. Based on findings from animal studies and the potential for serious adverse reactions related to these substrates for drugs that are sensitive to minimal concentration changes.

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