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Avoid strong CYP2C8 inhibitors, as they can decrease the plasma exposure to XTANDI. No dose adjustment is required for patients with mild renal impairment. For prolonged hematological toxicities, interrupt TALZENNA and XTANDI, including their potential benefits, and an approval in the risk of developing a seizure while taking XTANDI and for 3 months after receiving the last dose of XTANDI.

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