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Except as required by law, Lilly undertakes no duty to update forward-looking statements to reflect events after the date of this study reinforce the importance of diagnosing and treating disease sooner than we do today. This delay in progression meant that, on average, participants treated with donanemab once they reached a pre-defined level of plaque clearance. Lilly previously announced and published in the Journal of Medicine (NEJM) results from the Phase 2 TRAILBLAZER-ALZ study in 2021.
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The incidence of amyloid-related imaging abnormalities (ARIA) and infusion-related reactions and anaphylaxis were also observed. Results were similar across other subgroups, including participants who carried or did not carry an ApoE4 allele. If approved, we believe donanemab can provide clinically meaningful benefits for people with this disease and the majority will be consistent with the largest differences versus placebo seen at 18 months.
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