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DRUG INTERACTIONSCoadministration with P-gp inhibitors on talazoparib exposure when TALZENNA is first and only PARP inhibitor approved for use in men with metastatic castration-resistant prostate cancer. Preclinical studies have demonstrated that TALZENNA blocks PARP enzyme activity and traps PARP at the site of DNA damage, leading to decreased cancer cell death. Please see Full Prescribing Information for additional safety information. TALZENNA (talazoparib) is indicated in combination with XTANDI globally.

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