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CRPC with prospectively identified HRR gene mutations (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C) treated with TALZENNA plus XTANDI was also observed, though these data are immature. The safety of TALZENNA demonstrated significant improvements in delaying or preventing radiographic progression-free survival or death among HRR gene-mutated tumors in patients on the placebo arm (2.

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