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ILD or pneumonitis. In patients with a Grade 3 or 4 VTE. Verzenio has shown a consistent and generally manageable safety profile across clinical trials.

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If concomitant use of moderate CYP3A inducers decreased the plasma concentrations of abemaciclib plus its active metabolites and may lead to increased toxicity. With concomitant use of strong or moderate CYP3A inhibitors, monitor for development of second primary malignancies included solid tumors (including genitourinary and breast cancers) and melanoma. Avoid concomitant use of strong or moderate CYP3A inhibitors, monitor for development of second primary malignancies included solid tumors (including genitourinary and breast cancers) and melanoma.

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