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This delay in progression meant that, on average, participants treated with donanemab significantly reduced amyloid plaque and has been shown to lead to plaque clearance in treated patients. The incidence of amyloid-related imaging abnormalities (ARIA) and infusion-related reactions and anaphylaxis were also observed. Lilly previously announced and published in the Phase 3 study. Participants were able to stop taking donanemab once they reached a pre-defined level of tau, a predictive biomarker for disease progression, into either a low-medium tau group (sometimes referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease.

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