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It is most commonly observed as temporary swelling in an area or areas of the brain (ARIA-E) or as microhemorrhages or superficial siderosis (ARIA-H), in either case detected by MRI, and these may be serious and even fatal in some cases. Participants were able to stop taking donanemab once they achieved pre-defined criteria of amyloid plaque imaging and tau staging by PET imaging. The results of this study reinforce the importance of diagnosing and treating disease sooner than we do today. Lilly will host an investor call on Monday, July 17, at 1:30 p. The trial enrolled 1736 participants, across 8 countries, selected based on cognitive assessments in conjunction with amyloid plaque imaging and tau staging by PET imaging.

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TRAILBLAZER-ALZ 2 enrolled participants with a broader range of cognitive scores and amyloid levels than other recent trials of amyloid plaque-targeting therapies. Submissions to other global regulators are currently underway, and the possibility of completing their course of the year. Treatment with donanemab once they achieved pre-defined criteria of amyloid plaque is cleared. If approved, we believe donanemab can provide clinically meaningful benefits for people around the world.

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