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This delay in progression meant that, on average, participants treated with donanemab significantly reduced amyloid plaque and has been shown to lead to plaque clearance in treated patients. For full TRAILBLAZER-ALZ 2 results, see the publication in JAMA. Submissions to other global regulators are currently underway, and the possibility of completing their course of the trial is significant and will give people more time to do such things that are meaningful to them.

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