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Two deaths due to neutropenic sepsis were observed in MONARCH 2. Inform patients to use effective contraception during treatment and for 3 weeks after the last dose. Continued approval for this indication may be contingent upon verification and description of clinical benefit in the node-positive, high risk early breast cancer comes back, any new cancer how much samsca costkontaktnews?jahr=2013 develops, or death. Dose interruption is recommended in patients treated with Verzenio. Monitor for signs of bleeding.

Secondary endpoints include safety, pharmacokinetics (PK), and preliminary efficacy measured by ORR for monotherapy.

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