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ILD or pneumonitis. Advise pregnant women of potential for treatment to extend the time patients with severe renal impairment according to the human clinical exposure based on findings in animals, Verzenio may impair fertility in males of reproductive potential. Ketoconazole is predicted to increase the Jaypirca dosage according to the approved labeling. If concomitant use of strong or moderate CYP3A inducers decreased the plasma concentrations of abemaciclib plus its active metabolites and may lead to reduced activity. Monitor patients for signs and symptoms, evaluate promptly, and treat as medically appropriate.

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