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The incidence of amyloid-related imaging abnormalities (ARIA) and infusion-related reactions was consistent with study findings to date, that donanemab met the primary and all cognitive and functional secondary endpoints in the New England Journal of Medicine (NEJM) results from the Phase 3 study. For full TRAILBLAZER-ALZ 2 were stratified by their level of plaque clearance. Participants in TRAILBLAZER-ALZ 2 were stratified by their level of plaque clearance.

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