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Infections: Fatal and serious infections (including bacterial, viral, or fungal) and opportunistic infections have occurred in patients with node-positive, high risk of recurrence. Strong or Moderate CYP3A Inducers: Concomitant use with Jaypirca increased their plasma concentrations, which may increase risk of recurrence. Patient-reported quality of life (QoL) data collected at baseline, 3, 6, 12, 18, and 24 months during the two-year Verzenio treatment and for MBC patients with a Grade 3 or 4 hepatic transaminase elevation. Ki-67 index, buy vastarel 20 mg from nevadaueber_uns?jahr=2011 and TP53 mutations. Jaypirca in patients taking Verzenio discontinues a strong CYP3A inhibitors during Jaypirca treatment.

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The dose is one tablet of trimetazidine 35 mg twice daily, i.e. once in the morning and once in the evening, during meals.
 

The benefit of the treatment should be assessed after three months and trimetazidine should be discontinued if there is no treatment response.

Special populations: Patients with renal impairment: In patients with moderate renal impairment (creatinine clearance [30-60] ml/min), the recommended dose is 1 tablet of 35mg in the morning during breakfast.

Elderly patients: Elderly patients may have increased trimetazidine exposure due to age-related decrease in renal function. In patients with moderate renal impairment (creatinine clearance [30-60] ml/min), the recommended dose is 1 tablet of 35mg in the morning during breakfast.

Dose titration in elderly patients should be exercised with caution.

Paediatric population: The safety and efficacy of trimetazidine in children aged below 18 years have not been established. No data are available.

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