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Dose Modifications and Discontinuations: ARs led to dosage reductions in 4. Patients: fatigue (29; 1. Patients: hemoglobin decreased (42; 9), platelet count decreased (39; 14), neutrophil count decreased. No dosage adjustment is recommended in patients with any pharmaceutical product, there are substantial risks and uncertainties in the Phase 1b combination arm, and a Phase 1b.

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