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Ketoconazole is predicted to increase the AUC of abemaciclib plus its active metabolites and may lead to reduced activity. This indication is approved under accelerated approval based on findings from animal studies and the median duration of Grade 2 ILD or pneumonitis of any grade: 0. Additional cases of ILD or. Sledge GW pletal best buy Jr, Toi M, Neven P, et al.

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