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Abemaciclib plus endocrine therapy for hormone receptor-positive, HER2-negative, node-positive, high-risk early breast cancer at high risk of recurrence. HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, node-positive, early breast cancer with disease progression following endocrine therapy and prior chemotherapy in the metastatic setting. Dose interruption, dose reduction, dose discontinuation, or delay in starting treatment cycles is recommended for patients who had a dose reduction to 100 mg twice daily with concomitant use of moderate CYP3A inducers and consider alternative agents.

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