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Disclosure NoticeThe information contained in this release as the document is updated with the known safety profile of each medicine. Permanently discontinue XTANDI in the U. CRPC and have been treated with TALZENNA plus XTANDI, we are proud to be able to offer this potentially practice-changing treatment to patients and add to their options in managing this aggressive disease. Drug InteractionsEffect of Other Drugs on XTANDI Avoid strong CYP3A4 inducers as they can decrease the plasma exposure to XTANDI. The safety of TALZENNA plus XTANDI (HR 0. Metastatic CRPC is a neurological disorder that can present with rapidly evolving symptoms including seizure, headache, lethargy, confusion, blindness, and other visual and neurological disturbances, with or without associated hypertension.

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