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you have a stomach ulcer;
you have recent or recurring bleeding in your stomach or intestines;
you have kidney disease (especially if you also take dronedarone or ketoconazole);
you take certain other medicines that can increase bleeding risk, such as aspirin, clopidogrel (Plavix), heparin, prasugrel, warfarin (Coumadin, Jantoven);
you take an NSAID (nonsteroidal anti-inflammatory drug) on a regular basis, such as ibuprofen (Advil, Motrin), naproxen (Aleve), diclofenac, indomethacin, meloxicam, and others; or
you are older than 75.

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you have a genetic spinal defect;
you have a spinal catheter in place;
you have a history of spinal surgery or repeated spinal taps;
you have recently had a spinal tap or epidural anesthesia;
you are taking an NSAID--Advil, Aleve, Motrin, and others; or
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