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You should not use tolvaptan if you are allergic to it, or if:

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nefazodone;
an antibiotic--clarithromycin, telithromycin;
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HIV/AIDS medication--indinavir, nelfinavir, ritonavir, saquinavir.

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you have kidney disease or urination problems;
you have liver disease (especially cirrhosis);
you also take desmopressin (dDAVP), or a diuretic or "water pill";
you are malnourished; or
you have been drinking large amounts of alcohol.

It is not known whether tolvaptan will harm an unborn baby. Tell your doctor if you are pregnant.
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