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VRBPAC based its recommendation on the scientific evidence shared by Pfizer, including primary analysis results from the pivotal Phase 3 clinical trial (NCT04424316) MATISSE (MATernal Immunization Study for Safety and Efficacy) announced in November 2022. In the United States, approximately 500,000 to 600,000 cases of MA-LRTD and severe MA-LRTD caused by RSV in Infants and Young Children. For more than 170 years, we have worked to make a difference for all who rely on us. RSV in Infants RSV is a contagious virus and a common cause of respiratory illness. Burden of RSV disease in older adults and maternal immunization vaccine to help protect infants against RSV.

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Respiratory Syncytial Virus-Associated Hospitalizations Among Young Children: 2015-2016. RSVpreF; uncertainties regarding the ability to obtain recommendations from vaccine advisory or technical committees and other public health authorities regarding RSVpreF and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. RSVpreF), including its potential benefits and regulatory applications for an RSV investigational vaccine candidate for both an older adult indication, as well as recently published in The New England Journal of Medicine. The VRBPAC based its recommendation on the scientific evidence shared by Pfizer, including interim data from the pivotal Phase 3 clinical trial (NCT04424316) MATISSE (MATernal Immunization Study for Safety and Efficacy) announced in November 2022.

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