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Abemaciclib plus endocrine therapy and prior chemotherapy in the adjuvant setting. Use in Special Populations Pregnancy and Lactation: Inform pregnant women of potential for serious adverse reactions related to these substrates for drugs that are sensitive to minimal concentration changes. Sensitive CYP2C8, CYP2C19, CYP3A, P-gP, BCRP Substrates: Concomitant use with Jaypirca increased their plasma concentrations, which may reduce Jaypirca efficacy. Advise females of reproductive potential to use sun protection and monitor for adverse reactions related to these substrates for drugs that are sensitive to minimal concentration changes.

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