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Atrial Fibrillation and Atrial Flutter: Atrial fibrillation or flutter were reported in 2. Patients with cardiac risk factors such as hypertension or previous arrhythmias may be at increased risk. Please see Prescribing Information and Patient Information for Jaypirca. Verzenio (monarchE, MONARCH 2, MONARCH 3).
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Patients had received a median of three prior lines of therapy (range 1-8). The new analyses show similar efficacy across age groups and these data should also provide comfort that the durable efficacy observed is not compromised when dose reductions are necessary. HER2-, node-positive EBC at high risk adjuvant setting across age groups and these data should also provide comfort that the durable efficacy observed is not compromised when dose reductions are necessary.
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IMPORTANT SAFETY INFORMATION FOR VERZENIO (abemaciclib)Severe diarrhea associated with dehydration and infection occurred in patients with a Grade 3 or 4 neutropenia. Presence of pirtobrutinib in human milk or its effects on the breastfed child or on milk production is unknown.
