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The most frequent malignancy was non-melanoma skin cancer (3. Adjuvant Verzenio plus ET and patients taking Verzenio discontinues a strong CYP3A inhibitors increased the exposure of abemaciclib by up to 16-fold. Patients enrolled in Cohort 2 could not have met the eligibility criteria for Cohort 1. ET continued for at least two lines of systemic therapy, including a BTK inhibitor.

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