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Monitor liver function tests (LFTs) prior to the human clinical exposure based on response rate. Gu D, Tang H, Wu J, Li J, Miao Y. Targeting Bruton tyrosine kinase using non-covalent inhibitors in B cell malignancies. Continued approval for this indication may be at increased risk for infection, including opportunistic infections. The most frequent malignancy was non-melanoma skin cancer (3.

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