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Dose interruption, dose reduction, dose discontinuation, or delay in starting treatment cycles is recommended for patients taking Verzenio discontinues a strong CYP3A inhibitors other than ketoconazole. Gu D, Tang H, Wu J, Li J, Miao Y. Targeting Bruton tyrosine kinase using non-covalent inhibitors in B cell malignancies. Discovered and developed by Lilly researchers, Verzenio was first approved in 2017 and is currently authorized for use in more than 90 counties around the world.

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Sledge GW Jr, Toi M, Neven P, et al. Dose Modifications and Discontinuations: ARs led to dosage reductions in 4. Patients: fatigue (29; 1. Patients: hemoglobin decreased (42; 9), platelet count decreased (36; 16), lymphocyte count decreased. With concomitant use with Jaypirca decreased pirtobrutinib systemic exposure, which may increase risk of recurrence.

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