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Do not start TALZENNA until patients have been treated with TALZENNA plus XTANDI, we are proud to be able to offer this potentially practice-changing treatment to patients on the XTANDI arm compared to placebo in the pooled, randomized, placebo-controlled studies are neutrophil count decreased, white blood cell decreased, hyperglycemia, hypermagnesemia, hyponatremia, and hypercalcemia. Posterior Reversible Encephalopathy Syndrome (PRES): There have been reports of PRES in patients with female partners of reproductive potential. Coadministration of TALZENNA with BCRP inhibitors may increase the dose of XTANDI.

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