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The results of this study reinforce the importance of diagnosing and treating disease sooner than we do today. Donanemab specifically targets deposited amyloid plaque clearance. Among other things, there is no guarantee that planned or ongoing studies will be completed as planned, that future study results will be.

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Lilly previously announced and published in the New England Journal of the brain (ARIA-E) or as microhemorrhages or superficial siderosis (ARIA-H), in either case detected by MRI, and these may be serious and even fatal in some cases. ARIA occurs across the class of amyloid plaque clearing antibody therapies. This risk should be managed with careful observation, monitoring with MRIs, and appropriate actions if ARIA is detected.

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