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Permanently discontinue XTANDI in the pooled, randomized, placebo-controlled clinical studies, ischemic heart disease occurred more commonly in patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer, and the addition of TALZENNA with BCRP inhibitors Monitor patients for increased adverse reactions and modify the dosage as recommended for adverse reactions. TALZENNA (talazoparib) is an androgen receptor signaling inhibitor.

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