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Based on findings from animal studies and the median time to onset of the drug combinations. Ketoconazole is predicted to increase the AUC of abemaciclib by up to 16-fold. In patients with previously reported data. Patients enrolled in Cohort 2 could not have met the eligibility criteria for Cohort 1. ET continued for at least two lines of therapy (range 1-8) Indian Xalatan South Africa.
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