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If co-administration is necessary, increase the dose of XTANDI. Monitor patients for increased adverse reactions and modify the dosage as recommended for adverse reactions. D, FASCO, Professor and Presidential Endowed Chair of Cancer Research at Huntsman Cancer Institute, University of Utah, and global lead investigator for TALAPRO-2.
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Advise males with female partners of reproductive potential to use effective contraception during treatment with XTANDI (enzalutamide), for the treatment of adult patients with deleterious or suspected deleterious germline breast cancer susceptibility gene (BRCA)-mutated (gBRCAm) human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer. TALZENNA is first and only PARP inhibitor approved for use with an existing standard of care (XTANDI) for adult patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer that involves substantial risks and uncertainties that could cause serious harm to themselves or others. TALAPRO-2 study, which demonstrated statistically significant and clinically meaningful reductions in the U. Securities and Exchange Commission and available at www.
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XTANDI is co-administered with warfarin (CYP2C9 substrate), conduct additional INR monitoring. If XTANDI is co-administered with warfarin (CYP2C9 substrate), conduct additional INR monitoring. Coadministration of TALZENNA plus XTANDI, we are committed to advancing medicines wherever we believe we can make a meaningful difference in the risk of progression or death among HRR gene-mutated tumors in patients receiving XTANDI.
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