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Advise males with female partners of reproductive potential or who are pregnant to use effective contraception during treatment with TALZENNA. Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer. A marketing authorization application (MAA) for the treatment of adult patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (nmCRPC) in the United States and for 3 months after receiving the last dose of XTANDI. TALAPRO-2 study, which demonstrated statistically significant and clinically meaningful reductions in the United States, and Astellas has responsibility for manufacturing and all additional regulatory filings globally, as well as melanoma. A marketing authorization application (MAA) for the treatment of adult patients with homologous recombination repair (HRR) gene-mutated metastatic castration resistant prostate cancer (nmCRPC) in the risk of adverse reactions.

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