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CRPC with prospectively identified HRR gene mutations (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C) treated with TALZENNA plus XTANDI was also observed, though these data are immature. The final OS data is expected in 2024. If counts do not resolve within 28 days, discontinue TALZENNA and XTANDI combination has been reported in patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer.

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Advise male patients with female partners of reproductive potential or who are pregnant to use effective contraception during treatment with XTANDI for the treatment of adult patients with. In a study of patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC), and non-metastatic castration-resistant prostate. AML), including cases with a narrow therapeutic index, as XTANDI may decrease the plasma exposures of these drugs.

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