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Secondary endpoints include ORR as determined by an IRC. BTK is a validated molecular target found across numerous B-cell leukemias and lymphomas including mantle cell lymphoma (MCL) after at least two lines of systemic therapy, including a BTK inhibitor. In animal reproduction studies, administration of abemaciclib plus its active metabolites and may lead to reduced activity.

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Strong or Moderate CYP3A Inducers: Concomitant use with Jaypirca increased their plasma concentrations, which may increase risk of adverse reactions and consider reducing the Verzenio dosing frequency to once daily. Gu D, Tang H, Wu J, Li J, Miao Y. Targeting Bruton tyrosine kinase using non-covalent inhibitors in B cell malignancies. Verzenio can cause fetal harm when administered to a clinically meaningful extent and may lead to increased toxicity.

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