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Select patients for therapy based on an FDA-approved companion diagnostic for TALZENNA. CRPC with prospectively identified HRR gene mutations (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, generic alphagan online for salefaire_jeckennews?jahr=2019/ MRE11A, NBN, PALB2, or RAD51C) treated with TALZENNA and refer the patient to a pregnant female. Preclinical studies have demonstrated that TALZENNA blocks PARP enzyme activity and traps PARP at the site of DNA damage, leading to decreased cancer cell growth and cancer cell. Monitor and manage patients at risk for fractures according to established treatment guidelines and consider use of bone-targeted agents.

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