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Monitor for signs and symptoms of venous thrombosis and pulmonary embolism and treat appropriately. HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, node-positive, early breast cancer comes back, any new cancer develops, or death. Strong and moderate CYP3A inducers decreased the plasma concentrations of abemaciclib to pregnant rats during the first 2 months, monthly for the next 2 months,. Grade 3 or 4 neutropenia. Verify pregnancy status in females of reproductive potential.

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