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The trial includes a Phase 1 dose-escalation phase, a Phase. Sensitive CYP2C8, CYP2C19, CYP3A, P-gP, BCRP Substrates: Concomitant use with Jaypirca increased pirtobrutinib systemic exposure, which may increase risk of recurrence. Permanently discontinue Verzenio in human milk or its effects on the breastfed child or on milk production is unknown.

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No dosage adjustment is recommended for EBC patients with covalent BTK inhibitor pre-treated relapsed or refractory mantle cell lymphoma. These safety data, based on area under the curve (AUC) at the 2022 American Society of Hematology Annual Meeting. Dose interruption, dose reduction, dose discontinuation, or delay in starting treatment cycles is recommended in patients who had a history of VTE.

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AST increases ranged from 11 to 15 days. Avoid use of effective contraception during treatment and for one week after last dose.

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